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News from the QAS subcommittee

Presenting the Autoantibody Standardization sub-Committee (ASC)

 

The Committee for the Standardization of Autoantibodies in Rheumatic and Related Diseases was established in the early 1980s by Eng M. Tan, The Scripps Research Institute, La Jolla, based on the recognized critical needs for reference human autoimmune sera for academic, clinical, and industrial laboratories. The committee’s initial affiliation with the National Arthritis Foundation, Centers for Disease Control and Prevention, World Health Organization, and the International Union of Immunological Societies (IUIS) was instrumental to its early success in the recruitment of many investigators with expertise in autoantibody analysis. In recent years, the committee has used the shorter name “Autoantibody Standardization Committee (ASC)” with the affiliated website www.AutoAb.org. To date, the ASC remains a subcommittee of the Quality Assessment and Standardization Committee of the IUIS.

 


 

The primary objectives of the ASC are to uphold the highest standards of patient care by promoting accuracy in autoantibody testing. To date, 20 reference reagents are available free of charge and distributed to research laboratories, diagnostic laboratories, and commercial organizations developing autoantibody diagnostic kits. These reference reagents are now made available via the ASC website and distributed by Plasma Services Group Inc., Huntingdon Valley, Pennsylvania, USA.

Continuing education about autoantibodies is recognized as another major effort for the ASC. For the past 11 years, ASC has hosted a Study Group titled “Autoantibodies in Diagnosis and Follow-up of Rheumatic Diseases” at the annual scientific meeting of the American College of Rheumatology. A wide variety of topics have been covered including autoantibodies that may predict or prevent disease, many aspects of standardization of autoantibody testing, clinically relevant autoantibodies in idiopathic inflammatory myopathy, scleroderma and other diseases, the influence of genetics and environment in autoantibody production, and new methodological platforms.

A relatively new component of the ASC is the development of the International Consensus on ANA Patterns (ICAP) initiative. During the 12th International Workshop on Autoantibodies and Autoimmunity held in Sao Paulo, Brazil in 2014, a full-day session was devoted to discussion of consensus on morphological patterns observed in indirect immunofluorescence on HEp-2 cells. We have already run three additional workshops in Dresden, Germany, in 2015; Kyoto, Japan, in 2016; and Dresden again in 2017. Currently the ICAP website (www.ANApatterns.org) categorizes 30 ANA patterns and the consensus nomenclature and representative patterns are available online as well as in publications from the ICAP group. The goal of ICAP is to promote harmonization and understanding of autoantibody test nomenclature, as well as interpretation guidelines for ANA testing, thereby optimizing usage in patient care. To date, the ICAP website has been translated into Spanish, Portuguese, German, Italian, French, Chinese, and Turkish and visited more than 70,000 times from 144 countries including over 1,000 registered users/members.

Autoantibody standardization is a continuing process as new autoantibodies are identified, and new technology platforms are incorporated into autoantibody assays. It is critical to validate results in the new assays with established standard assays in additional follow-up or post market studies.

Professor Edward K. L. Chan, Ph.D.
Chair, the Autoantibody Standardization Committee
University of Florida
Gainesville, Florida
USA




 
Advanced Course on T cell memory

Anacapri, Capri  island (Naples, Italy), 12-15 October, 2018

Directors

Stephen Schoenberger (USA) & Francesca Di Rosa (Italy)

The Course will offer an overview of key cellular and molecular signals required for a durable T cell response, focusing on emerging themes in the field. Fundamental questions and translational implications will be discussed. Participants will have plenty of opportunity for scientific interactions and networking in a friendly atmosphere.

Deadline for application July 3, 2018

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Post-doctoral fellow position in France

Understanding injury-induced immunosuppression

The Joint Research Unit between the Hospices Civils de Lyon (HCL) and bioMérieux is looking for a post-doctoral fellow to work on the REALISM project whose goal is to identify and validate new markers for improving care of patients presenting high risk of sepsis (Rol et al., BMJOpen, 2017).

Read more...
 
Clinical Immunology Training Course at ECI 2018

The CIC Committee is happy to invite you to the Clinical Immunology Course to be held in

Amsterdam, on Sunday, September 2nd

9 a.m. to 12.25 p.m.

in the occasion of the ECI 2018

See the preliminary program:

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Call for IUIS 2019 Speakers and Chairs - deadline extended

It is with great pleasure that the International Union of Immunological Societies (IUIS) Executive Committee invites your National or Regional IUIS Society to nominate the best and brightest from your own constituents to be a Speaker or Chair at the IUIS 2019.


The IUIS 2019 International Congress will be held in Beijing on October 19-23. It is an ideal opportunity for your members to take center stage at one of the most prestigious international immunological conferences. Your participation will make the Congress a special one and ensure that it truly represents global immunological science.

Instructions for nominations:

To submit your nominations, kindly fill in the provided Sumbission Form. Have a look at the list of topic proposal for Symposia topic suggestions -new ideas are also welcome! Each Society or Federation can propose up to 10 names (1 nomination per page), while bearing gender parity in mind.

Nominations must be sent to the IUIS 2019 team ( This e-mail address is being protected from spambots. You need JavaScript enabled to view it ) before July 15, 2018

 
Changes to the IUIS Legal Notice and Private Policy

On May 25, 2018, we are updating our Legal Notice and Private Policy to ensure our privacy guidelines keep step with best practices. We encourage you to read them carefully.  Using our website after that date will indicate your agreement to be bound by the new Legal Notice and Private Policy.

Here are the key updates:

  • Easier to read and navigate: we have reorganized the 2 documents, making it easier to understand IUIS’s relationship with its members and website users
  • GDPR compliance: You can, at any time, request the following:
    • Be permanently deleted from our records
    • Access, correction, edit or deletion of the data we hold about you
    • Portability of the data we hold about you
    • Opt-out of inclusion of your data in a specific project (newsletter, postal mailing etc.)

Please be assured we will treat your information with the utmost care and will never sell it to third parties for marketing purposes. Should you have any question, do not hesitate to contact us at This e-mail address is being protected from spambots. You need JavaScript enabled to view it .

Thank you,

IUIS Central Office

 
Early Career Research Prize in Vaccinology R&D

Applications open!

Early Carreer Research Prize in Vaccinology

Once again this year, the IUIS, together with Vaccines Europe will collect applications from members of IUIS, EFIS or any other European Immunology and/or Vaccinology Society and select a winner among them.

The aim is to promote and foster a younger generation of scientists in the early stages of their career in Europe.

Deadline for application submission: 30st June 2018

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ImmunoKenya Workshop 2018

How viruses hijack host immunity leading to cancers

KCB Leadership Center, Nairobi, Kenya - September 23-28

Open to advanced graduate, MD students and postdoctoral fellows. Immuno-Kenya 2018 will  provide an interactive forum with international faculty, focusing on how HIV, HCV, HTLV, HPV and EBV infections lead to cancers.

Application deadline July 1, 2018 by midnight EAT

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AAI Advanced Course in Immunology 22-27 July 2018

Register now: http://www.aai.org/Education/Courses/Advanced

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